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Low vitamin B12, which can sometimes happen with low iron or poor nutrition, may lead to darker lips

doi: 10.1007/s00223-016-0179-6 22

By increasing the hydrophilicity of compounds, both phases facilitate their elimination through urine or bile

The resulting elevated TSH promotes thyroid gland enlargement, or goiter, with metabolic slowing in affected animals

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It has been reported that plasminogen activator inhibitor-1 gene expression in endothelial cells and vascular remodeling are normalized by ROCK inhibitor treatment in atherosclerosis models [83, 84]